Mainly because clinical trials are carried out less than widely varying circumstances, adverse reaction prices observed during the medical trials of the drug can't be immediately compared to fees from the medical trials of Yet another drug and may not replicate the fees noticed in medical apply.
Even so, because greater plasma amounts may possibly improve the incidence of adverse reactions, a starting up dose of twenty five mg need to be viewed as in more mature subjects as a consequence of the upper systemic publicity [see DOSAGE AND ADMINISTRATION].
At doses earlier mentioned the suggested dose vary, adverse reactions have been comparable to Individuals in-depth in Table one beneath but generally ended up described far more frequently.
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